Fanelli Cafe, Soho, Manhattan
Fanelli Cafe isn't really a cafe at all. It is a restaurant and bar and it's considered to be "the city's second-oldest food-and-drink establishment in the same locale, having operated under various owners at 94 Prince Street since 1847." It has quite a history including the fact that The Beats were regulars there as was Bob Dylan and also most of the artists who lived in Soho in the 1980s frequented Fanelli's and discussed their work there.
I've had drinks and food at Fanelli's on a few occasions and it is typically filled with locals and a few tourists or shoppers. If you're looking to explore some of NYC's history while having food and drink, this is a great place to do it! During prohibition they operated as a speakeasy!
Fanelli Cafe, 94 Prince Street at the corner of Mercer Street