Artists and Fleas, Soho, Manhattan
Update - this location has closed
Artists and Fleas opened their first location in Williamsburg in 2003. That location is open on weekends only. They also have a location in the Chelsea Market which opened in 2014. The Soho location opened in 2017.
Each of the different locations for Artists and Fleas features different independent artists and locations. They often have a live DJ and a very diverse assortment of indie businesses. This location also has a mini Strand Bookstore with a small assortment of popular books and lots of their merchandise.
There are at least 5 or 6 shops on Broadway in Soho that are similar in that they sell products from independent businesses.
Artists and Fleas - 490 Broadway at Broome Street